ABSTRACT
Ecchino coccosis or hydatid cyst disease is a common parasitic disease that is known to affect both humans and animals and is an important health problem in poorly developed countries. In this histopathological retrospective study, we aimed to evaluate hydatid cyst disease occurring at different sites of body and were diagnosed during last fifteen years in pathology department, Liaquat University of Medical and Health Sciences [LUMHS], Jamshoro from January 1996 to December 2010. Descriptive retrospective study. A total of 80 cases of hydatid cyst disease of different organs diagnosed at pathology department LUMHS Jamshoro and retrieved from Histopathological record. Out of these 80 cases, 56 cases [70%] were of liver, 8 [10%] of lung, 5 [6.25%] of ovary. 01 case [1.2%] thyroid, 02 cases [2.5%] submandibular region and 8 [10%] each occurring at thigh, forearm, palm, cheek and fronto-temporal region. Majority of cases seen in females and M/F ratio of 1:3.6 and with age range of 8-65 years. More than 50% of cases were seen between 30-65 years of age. Hydatid cyst of liver was most common site followed by lung. But it can also be included in differential diagnosis of solitary cystic lesions of ovary and thyroid as well
ABSTRACT
Pancytopenia is a serious haematological problem, which makes the patient prone to anaemic manifestations, infections and bleeding tandency. Underlying it are many diseases, which are diagnosed by bone marrow aspiration and trephine biopsy. This study was done to describe different etiological causes of pancytopenia in adults population of lower Sindh. Cross sectional study. The study was carried out in the department of pathology and diagnostic and research laboratory, Liaquat University of Medical and Health Sciences [LUMHS] Hyderabad in collaboration with medical units of LUMHS Jamshoro from January 2009 to June 2010. A total of 100 adult patients with Pancytopenia diagnosed on peripheral blood smear examination were admitted in four medical units of LUMHS Jamshoro during study period, were followed by bone marrow examination and trephine biopsy wherever required. Megaloblastic anaemia was diagnosed in 46% cases, followed by aplastic anaemia in 22% and Acute leukaemia in 10% cases and 5% cases each were diagnosed as hyperspleenism and disseminated tuberculosis. Multiple myelomas were diagnosed in 4% cases, Meylodysplastic syndrome in 3% and Non-Hodgkins lymphoma is seen in 3% and Myelo-fibrosis in 2% cases. It is concluded that Megaloblastic anaemia is most common cause of Pancytopenia in our series followed by aplastic anaemia and acute leukaemia
ABSTRACT
To determine the frequency and types of different pathological lesions seen in pleural biopsies in our patients. This is a prospective study carried out in the Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. A total of 155 pleural biopsies over a period from 01st January 2007 to 30th June 2008 were reviewed. Haemotoxylin and Eosin [H and E] stained slides were examined to determine the various non- neoplastic and neoplastic lesions. Special stains were performed whenever required. Out of 155 cases of pleural biopsies, 110 cases were diagnosed as non-neoplastic lesions and 29 as neoplastic lesions. The remaining 16 cases were found inconclusive. The non-neoplastic lesions included chronic granulomatous inflammation consistent with tuberculosis 47 cases, chronic non-specific inflammation 42 cases and empyema 21 cases. Chronic granulomatous inflammation consistent with tuberculosis was found to be commonest non-neoplastic lesion with male predominance and maximum number of cases was seen in 2nd decade of life. Neoplastic lesions included adenocarcinoma 26 cases followed by undifferentiated small cell carcinoma, squamous cell carcinoma and malignant lymphoma each comprising single case. Adenocarcinoma was found to be commonest neoplastic lesion with slight female predominance and maximum number of cases was seen in 5th decade of life. The commonest non-neoplastic pleural biopsy lesion was found to be tuberculosis and the commonest neoplastic lesion was adenocarcinoma in pleural biopsy